发明名称 |
PRODUCTS AND THEIR USE FOR THE DIAGNOSIS, PREVENTION AND/OR CARE OF HUMAN AND/OR ANIMAL PATHOLOGIES CHARACTERISED BY THE ANOMALOUS DEPOSITION OF B-AMYLOID AND/OR AMYLOID-LIKE SUBSTANCE IN HUMAN AND/OR ANIMAL ORGANS AND TISSUES, AND SCREENING METHOD FOR DETERMINING THE RISK OF SUCH PATHOLOGIES |
摘要 |
The patent refers to a screening method carried out on biological material isolated from human and/or animal organisms for determining the risk of human and/or animal pathologies expressing an anomalous deposition of &bgr;-amyloid and/or amyloid-like substance in human and/or animal organs and tissues, based on the investigation of the punctiform mutation Ala>Val in position 2 of the &bgr;-protein (corresponding to the Ala673Val mutation precursor of the &bgr;-protein containing 770 amino acids) in homozygosis or in heterozygosis. The patent provides for the possibility of: (1) creating unicellular or multicellular transgenic organisms expressing the Ala673Val mutation; (2) synthesising or producing peptides with such mutation and/or their derivatives and/or nucleic acids containing the same mutation; (3) using such products for studying the pathogenesis of the pathologies characterised by anomalous deposition of &bgr;-amyloid and/or amyloid substance and for the prevention, diagnosis and care of such diseases.
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申请公布号 |
US2011010785(A1) |
申请公布日期 |
2011.01.13 |
申请号 |
US20080682578 |
申请日期 |
2008.10.10 |
申请人 |
FONDAZIONE I.R.C.C.S ISTITUTO NEUROLOGICO "CARLO BESTA" |
发明人 |
DIFEDE GIUSEPPE;MORBIN MICHELA;TAGLIAVINI FABRIZIO;MARTINI ALFREDO |
分类号 |
A61K48/00;A01K67/027;A01K67/033;A61K38/08;A61P25/28;C07H21/02;C07H21/04;C07K7/06;C07K14/00;C12N5/10;C12Q1/68 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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