发明名称 |
Process for the manufacture of the calcium salt of rosuvastatin and crystalline intermediates thereof |
摘要 |
A process for the manufacture of the calcium salt of (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3 R ,5 S )-3,5-dihydroxyhept-6-enoic acid, useful as an HMGCoA reductase inhibitor, from a compound of the formula (7)
wherein A is an acetal or ketal protecting group and R is alkyl, via isolated crystalline compounds of the formula (8) or of formula (10)
is described. Crystalline intermediates of formulae 7, 8 and 10 are also described. |
申请公布号 |
EP2272842(A1) |
申请公布日期 |
2011.01.12 |
申请号 |
EP20100183668 |
申请日期 |
2004.10.22 |
申请人 |
ASTRAZENECA UK LIMITED;SHIONOGI & CO., LTD. |
发明人 |
HORBURY, JOHN;LAFFAN, DAVID, DERMOT, PATRICK;OKADA, TETSUO |
分类号 |
C07D405/06;C07D239/42 |
主分类号 |
C07D405/06 |
代理机构 |
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代理人 |
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