发明名称 |
PHENYLETHANOIC ACID, PHENYLPROPANOIC ACID AND PHENYLPROPENOIC ACID CONJUGATES AND PRODRUGS OF HYDROCODONE, METHOD OF MAKING AND USE THEREOF |
摘要 |
The presently described technology provides phenylethanoic acid, phenylpropanoic acid, phenylpropenoic acid, a salt thereof, a derivative thereof or a combination thereof chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs or compositions of hydrocodone which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
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申请公布号 |
US2011002991(A1) |
申请公布日期 |
2011.01.06 |
申请号 |
US20100828456 |
申请日期 |
2010.07.01 |
申请人 |
MICKLE TRAVIS;GUENTHER SVEN;MICKLE CHRISTAL;CHI GUOCHEN;KANSKI JAROSLAW;MARTIN ANDREA K;BERA BINDU |
发明人 |
MICKLE TRAVIS;GUENTHER SVEN;MICKLE CHRISTAL;CHI GUOCHEN;KANSKI JAROSLAW;MARTIN ANDREA K.;BERA BINDU |
分类号 |
A61K9/28;A61K31/485;A61P25/30;A61P25/36;A61P29/00;C07D489/04 |
主分类号 |
A61K9/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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