摘要 |
The presently described technology provides phenylethanoic acid, phenylpropanoic acid, phenylpropenoic acid, a salt thereof, a derivative thereof or a combination thereof chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs or compositions of hydrocodone which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology. |
申请人 |
KEMPHARM, INC.;MICKLE, TRAVIS;GUENTHER, SVEN;MICKLE, CHRISTAL;CHI, GUOCHEN;KANSKI, JAROSLAW;MARTIN, ANDREA, K.;BERA, BINDU |
发明人 |
MICKLE, TRAVIS;GUENTHER, SVEN;MICKLE, CHRISTAL;CHI, GUOCHEN;KANSKI, JAROSLAW;MARTIN, ANDREA, K.;BERA, BINDU |