STENT WITH DIFFERENTIAL TIMING OF ABLUMINAL AND LUMINAL RELEASE OF A THERAPEUTIC AGENT

摘要

A stent designed for implantation into a blood vessel of a patient comprising:
a tubular stent sidewall structure comprising a plurality of struts and openings in the sidewall structure; wherein at least one strut comprises an abluminal surface, a luminal surface opposite the abluminal surface, and side surfaces extending between the luminal and abluminal surfaces;
a first coating composition disposed on the abluminal surface and luminal surface;
and
a second coating composition disposed on a portion of the first coating composition; characterized in that
the portion is disposed either
only on the abluminal surface and side surfaces or
only on the abluminal surface; and
when the stent is implanted, the second coating composition disposed on the abluminal surface faces the blood vessel.