| 发明名称 |
TEST AND MODEL FOR ALZHEIMER'S DISEASE |
| 摘要 |
<p>Model systems of Alzheimer's disease comprise a DNA sequence encoding an amy-loid precursor protein (APP) isoform or fragment that has an amino acid substitution. The substituted amino acid may be other than valine at the amino acid position corresponding to amino acid residue position 717 of APP770. Methods of determining genetic predisposi-tion to Alzheimer's disease are also disclosed.</p> |
| 申请公布号 |
CA2101774(C) |
申请公布日期 |
2011.01.04 |
| 申请号 |
CA19922101774 |
申请日期 |
1992.01.21 |
| 申请人 |
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY & MEDICINE |
发明人 |
HARDY, JOHN A.;CHARTIER-HARLIN, MARIE-CHRISTINE;GOATE, ALISON M.;OWEN, MICHAEL J.;MULLAN, MICHAEL J. |
| 分类号 |
A61K38/00;C12N15/12;A01K67/00;A01K67/027;A61P25/28;C07K14/00;C07K14/47;C07K14/575;C07K16/00;C12N1/21;C12N5/10;C12N15/00;C12N15/09;C12N15/85;C12P21/02;C12Q1/02;C12Q1/68;G01N33/15;G01N33/50;G01N33/53;G01N33/566;G01N33/577 |
主分类号 |
A61K38/00 |
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