HIGHLY STABLE ADJUVANTS COMPRISING POLYMERIC EMULSIFIER AS STABILIZER

摘要

PURPOSE: An immune enhancer composition containing polymer emulsifier as a stabilizing agent and a vaccine composition containing the same are provided to continuously maintain immunity and to ensure formulation stability. CONSTITUTION: An immune enhancer composition contains oil ingredient, non-ionic emulsifier, aqueous ingredient and polymer emulsifier of A-B-A type block copolymer. A and B are denoted by chemical formula 1 and 2, respectively. The molecular weight of A and B is 500-50,000 each. A polymer emulsifier is contained in 0.1-5.0 weight% based on total weight. The immune enhancer is an emulsion of water-in-oil form. A vaccine composition contains the immune enhancer composition and biologically acceptable amount of immunogenic material.