| 发明名称 |
BENZODIAZEPINE COMPOUND AND PHARMACEUTICAL COMPOSITION |
| 摘要 |
The present invention provides a novel benzodiazepine compound that blocks the IKur current or the Kv1.5 channel potently and more selectively than other K+ channels. The benzodiazepine compound of the invention is represented by General Formula (1) wherein R1, R2, R3, and R4 are each independently hydrogen or lower alkyl; R2 and R3 may be linked to form lower alkylene; A1 is lower alkylene optionally substituted with one or more hydroxy; and R5 is group represented by wherein R6 and R7 are each independently hydrogen or organic group; XA and XB are each independently bond, lower alkylene, etc.
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| 申请公布号 |
US2010331317(A1) |
申请公布日期 |
2010.12.30 |
| 申请号 |
US20090918226 |
申请日期 |
2009.02.20 |
| 申请人 |
OSHIMA KUNIO;OSHIYAMA TAKASHI;TAIRA SHINICHI;MENJO YASUHIRO;YAMABE HOKUTO;MATSUMURA SHUUJI;UEDA MASATAKA;KOGA YASUO;TAI KUNINORI;NAKAYAMA SUNAO;ONOGAWA TOSHIYUKI;TSUJIMAE KENJI |
发明人 |
OSHIMA KUNIO;OSHIYAMA TAKASHI;TAIRA SHINICHI;MENJO YASUHIRO;YAMABE HOKUTO;MATSUMURA SHUUJI;UEDA MASATAKA;KOGA YASUO;TAI KUNINORI;NAKAYAMA SUNAO;ONOGAWA TOSHIYUKI;TSUJIMAE KENJI |
| 分类号 |
A61K31/551;A61P9/06;C07D243/12;C07D401/14;C07D405/14;C07D413/14;C07D417/14 |
主分类号 |
A61K31/551 |
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