发明名称 |
Multivalent immunoglobulin-based bioactive assemblies |
摘要 |
The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Preferred embodiments concern hexameric stably tethered structures comprising one or more IgG antibody fragments and which may be monospecific or bispecific. The disclosed methods and compositions provide a facile and general way to obtain stably tethered structures of virtually any functionality and/or binding specificity. The stably tethered structures may be administered to subjects for diagnostic and/or therapeutic use, for example for treatment of cancer or autoimmune disease. The stably tethered structures may bind to and/or be conjugated to a variety of known effectors, such as drugs, enzymes, radionuclides, therapeutic agents and/or diagnostic agents.
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申请公布号 |
US7858070(B2) |
申请公布日期 |
2010.12.28 |
申请号 |
US20090396605 |
申请日期 |
2009.03.03 |
申请人 |
IBC PHARMACEUTICALS, INC. |
发明人 |
CHANG CHIEN-HSING;GOLDENBERG DAVID M.;ROSSI EDMUND A. |
分类号 |
C07K16/46;A61K38/18;A61K38/19;A61K38/20;A61K39/395;A61K49/16;A61K51/10;C07K16/22;C07K16/28;C07K16/30 |
主分类号 |
C07K16/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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