发明名称 |
DAA PERIPHERAL BENZODIAZEPINE RECEPTOR LIGAND FOR CANCER IMAGING AND TREATMENT |
摘要 |
Peripheral Benzodiazepine Receptor (PBR) is an attractive target for tumor imaging and treatment due to its up-regulation in numerous cancer cell types. DAA1 106 is a selective PBR ligand with high binding affinity. Aspects of the present invention are series of functionalized DAA1 106 analogs, which can be conjugated to a variety of signaling and treatment moieties, and are widely applicable in PBR targeted molecular imaging and drug delivery.
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申请公布号 |
US2010324130(A1) |
申请公布日期 |
2010.12.23 |
申请号 |
US20070518067 |
申请日期 |
2007.12.05 |
申请人 |
BORNHOP DARRYL J;BAI MINGFENG |
发明人 |
BORNHOP DARRYL J.;BAI MINGFENG |
分类号 |
A61K31/335;A61K31/16;A61P35/00;C07C233/00;C07C237/00;C07D403/06;C07D493/00;G01N21/00 |
主分类号 |
A61K31/335 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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