发明名称 |
DNA REPAIR POLYPEPTIDES AND METHODS OF DELIVERY AND USE |
摘要 |
Described herein are pyrimidine dimer-specific glycosylase (PDG) polypeptides and methods of use for repair of damaged DNA. The PDG polypeptides comprise amino acid sequence from T4-PDG, CV-PDG or engineered mutants thereof. The PDG polypeptides further comprise a targeting sequence, such as a nuclear targeting sequence or a mitochondrial targeting sequence, and a protein transduction domain. The mutant PDG polypeptides described herein retain at least some catalytic activity while exhibiting reduced cytotoxicity in wild-type cells.
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申请公布号 |
US2010322916(A1) |
申请公布日期 |
2010.12.23 |
申请号 |
US20090865213 |
申请日期 |
2009.01.30 |
申请人 |
MCCULLOUGH AMANDA K;LLOYD R STEPHEN |
发明人 |
MCCULLOUGH AMANDA K.;LLOYD R. STEPHEN |
分类号 |
A61K38/47;C07H21/04;C12N5/00;C12N5/02;C12N9/24;C12N15/63 |
主分类号 |
A61K38/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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