发明名称 |
Methods for in vitro differentiation of Th-17+cells |
摘要 |
The present invention is directed to an in vitro method for promoting differentiation and proliferation of human T helper lymphocytes that express IL17 (Th-IL17+ cells). The instant method may be used to generate a population of human T helper lymphocytes that express IL 17 (Th-IL 17+ cells) in vitro. Methods for screening to identify agents capable of modulating Th-IL17+ cell differentiation are also encompassed by the present invention. Isolated, pure populations of homogeneous Th-IL17+ cells that do not express cellular markers characteristic of Th1, Th2, or Treg cells are also encompassed herein.
|
申请公布号 |
US2010323383(A1) |
申请公布日期 |
2010.12.23 |
申请号 |
US20090386355 |
申请日期 |
2009.04.15 |
申请人 |
MANEL NICOLAS;LITTMAN DAN R |
发明人 |
MANEL NICOLAS;LITTMAN DAN R. |
分类号 |
C12Q1/02;C12N5/00;C12N5/071;C12N15/86 |
主分类号 |
C12Q1/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|