PROCESS FOR THE PREPARATION OF AMORPHOUS RABERAZOLE SODIUM

摘要

The present invention provides a process for the preparation of amorphous rabeprazole sodium said process comprising (a) suspending rabeprazole in an organic solvent having dielectric constant ranging between 1.8 to 21, wherein at least 80 % of the organic solvent is a ketonic solvent having dielectric constant ranging between 13 to 21; (b) adding aqueous sodium hydroxide; (c) azeotropically distilling out water from the above reaction system to obtain a residue, (d) adding ketonic solvent having dielectric constant ranging between 13 to 21 to the residue of step (c) to obtain a solution; and (e) quenching the solution obtained in step (d) into an organic solvent having a dielectric constant ranging between 1.8 to 21, wherein at least 80 % of the organic solvent is an ethereal solvent having dielectric constant ranging between 1.8 to 5.