发明名称 |
DOUBLE-STRANDED LIPID-MODIFIED RNA HAVING HIGH RNA INTERFERENCE EFFECT |
摘要 |
An object of the present invention is to provide a novel double-stranded RNA that has high resistance to nuclease and cellular uptake efficiency and that can produce an excellent RNA interference effect. The present invention provides a double-stranded lipid-modified RNA comprising a sense strand having a nucleotide sequence complementary to a target sequence in a target gene, and an antisense strand having a nucleotide sequence complementary to the sense strand, the double-stranded RNA being capable of suppressing the expression of the target gene, and the sense strand having a double-stranded lipid bound directly or via a linker to at least one of the first to sixth nucleotides from the 5' end. |
申请公布号 |
EP2264167(A1) |
申请公布日期 |
2010.12.22 |
申请号 |
EP20090729165 |
申请日期 |
2009.03.31 |
申请人 |
NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCEAND TECHNOLOGY;OTSUKA PHARMACEUTICAL CO., LTD.;HAYASHI KASEI CO., LTD. |
发明人 |
KUBO, TAKANORI;OHBA, HIDEKI;TOYOBUKU, HIDEKAZU;HAYASHI, HIROTAKE |
分类号 |
C12N15/09;A61K31/7088;A61K48/00 |
主分类号 |
C12N15/09 |
代理机构 |
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地址 |
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