SUSTAINED-RELEASE TABLET CONTAINING ALFUZOSINE HCL

摘要

PURPOSE: A sustained release tablet is provided to suppress interlayer separation and to ensure excellent release pattern. CONSTITUTION: A sustained release tablet comprising: an upper layer containing 0.2 weight parts of alfuzosine hydrochloric acid, 90 weight parts of hydroxypropylmethyl cellulose, 29.6 weight parts of polyethylene oxide, 1 weight part of stearylalcohol, 0.4 weight parts of hard silicon dioxide and 1 weight part of ethyl cellulose; and a lower layer containing 9,8 weight parts of alfuzosine hydrochloric acid, 36-62 weight part of microcrystalline cellulose, 24-60 weight parts of polyethylene oxide and 20 weight parts of low substituted propylcellulose, 1-6 weight parts of stearyl alcohol, and 99 weight parts of hydroxypropyl cellulose.