发明名称 |
3-spiro-cyanin fluorochromes and their use in bioassays |
摘要 |
The invention concerns sterically shielded, stabilized fluorescent dyes based on symmetrical or unsymmetrical 3-spirocyanines and their utilization as marker-molecules in analytical procedures. The fluorescent dyes according to the invention are characterized by a strongly reduced proneness towards aggregation due to the insertion of bulky spiro-substituents and thus enable to reach a high degree of coupling to the target molecule without a significant loss of fluorescence due to self quenching effects. They therefor exhibit a high quantum yield and are thus excellently suitable as fluorescent dyes, especially as NIR-fluorescent dyes, for the coupling or binding to biological and non-biological target molecules used in analytical methods. The analytical methods comprise all methods in which fluorescence-optical methods are used to detect biological and non-biological molecules.
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申请公布号 |
US7855293(B2) |
申请公布日期 |
2010.12.21 |
申请号 |
US20020130547 |
申请日期 |
2002.09.19 |
申请人 |
HAALCK LUTZ;GEDIG ERK;HOELPERT HANS-JUERGEN;PODSADLOWSKI VIOLA |
发明人 |
HAALCK LUTZ;GEDIG ERK;HOELPERT HANS-JUERGEN;PODSADLOWSKI VIOLA |
分类号 |
C07D401/04;C07D209/54;C07D491/107;C09B23/02;G01N33/533 |
主分类号 |
C07D401/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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