摘要 |
Disclosed herein are methods for treating respiratory disorders via administration of antisense compounds targeting IL-4Ra. Provided herein, for example, are compositions and methods for managing, treating, ameliorating, preventing and/or delaying the onset of pulmonary inflammation, airway hyperreactivity and/or loss of lung function, or a symptom thereof in a subject. Further provided, for example, are compositions and methods of inducing or augmenting hypo-responsiveness, non-responsiveness or tolerance to an antigen in a subject. Also provided, for example, are compositions and methods of enhancing the efficacy of a vaccine in a subject. In certain embodiments, the compositions and methods provided herein utilize an antisense compound 12 to 35 nucleobases in length targeted to a nucleic acid molecule encoding human IL-4 receptor alpha IL-4Ra, wherein said antisense compound inhibits expression of human IL-4Ra protein and/or expression of functional IL-4 and IL- 13 receptors. |
申请人 |
ALTAIR THERAPEUTICS, INC.;ISIS PHARMACEUTICALS, INC.;GREGORY, SUSAN;KARRAS, JAMES, G.;CROSBY, JEFFREY, R.;YU, ZHENGRONG;GEARY, RICHARD, S. |
发明人 |
GREGORY, SUSAN;KARRAS, JAMES, G.;CROSBY, JEFFREY, R.;YU, ZHENGRONG;GEARY, RICHARD, S. |