COMPOSITIONS AND METHODS FOR DELIVERING INHIBITORY OLIGONUCLEOTIDES
摘要
The present invention features compositions and methods that make use of complexes comprising one or more inhibitory nucleic acids and a targeting polypeptide, wherein the targeting polypeptide consists of a cell surface receptor ligand. The compositions can be used in methods of silencing gene expression in a cell, in delivering agents to a target cell, and in treating or preventing a disease or disorder in a subject.
申请公布号
WO2009129281(A3)
申请公布日期
2010.12.16
申请号
WO2009US40607
申请日期
2009.04.15
申请人
GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH &HUMAN SERVICES;ARYA, BIRA;OLKHANUD, PUREVDORJ;ESPINOZA, JUAN