| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide methods and compositions useful in diagnosing and treating hepatic disorders, especially those characterized by inflammation. <P>SOLUTION: Isolated antibodies which are combined with the epitope on an MAdCAM are disclosed. These compositions are useful in treating diseases or disorders involvingα4β7/MAdCAM blockade, as well as inhibiting a primary event in the inflammatory response such as blocking interactions between intercellular adhesion molecules and their ligands. Treatable disorders include infections, especially viral infections, iatrogenic disorders, cholestatic disorders, hereditary disorders, sarcoidosis, organ transplant, and the like. The diagnostic methods of the antibodies can be employed to detect the presence of a disorder or to monitor the course of therapy used to treat the disorder. <P>COPYRIGHT: (C)2011,JPO&INPIT</p> |
