INFLUENZA VACCINES WITH ENHANCED IMMUNOGENICITY AND USES THEREOF

摘要

The present invention generally relates to Influenza vaccine compositions and methods of use. One aspect of the present invention relates to a vaccine composition comprising a pharmaceutically acceptable carrier and an antigen preparation, the antigen preparation comprising an influenza virus nucleoprotein (NP) polypeptide, and optionally an influenza virus matrix (M) protein. Another aspect of the present invention relates to an influenza virus vaccine composition and methods of use, comprising an influenza virus NP and/or M protein and a Bacillus anthracis lethal factor (LF) polypeptide, such as a LFn polypeptide, a N-terminal portion of the LF polypeptide. In some embodiments, the LF polypeptide can be fused or otherwise associated with the NP or M polypeptide, or alternatively, or in addition, associated with any or all of the influenza virus antigen polypeptides (e. g. HA, NA, etc) in the vaccine composition.