摘要 |
<p>The invention relates to bacterial promoter elements which constitute or which are comprised in promoter regions and which confer tumour specificity to the promoter region activity, resulting in transcription of a transgene, which can be a heterologous or a homologous gene, which transgene is functionally arranged downstream of the promoter region at presence of a host bacterium in tumour tissue, while essentially conferring inactivity of the promoter region and no transcription at presence of the host bacterium in non-tumour tissue. Accordingly, the invention relates to bacterial promoter regions containing these tumour specific promoter elements.</p> |
申请人 |
HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH;WEISS, SIEGFRIED;BARTELS, SARA;LOESSNER, HOLGER;DEYNEKO, IGOR;BUMANN, DIRK;WESTPHAL-DANIEL, KATHRIN |
发明人 |
WEISS, SIEGFRIED;BARTELS, SARA;LOESSNER, HOLGER;DEYNEKO, IGOR;BUMANN, DIRK;WESTPHAL-DANIEL, KATHRIN |