发明名称 |
PROCESS FOR THE PRODUCTION OF BENZOFURANS |
摘要 |
A process for the production of 2-alkyl-3-aroyl-5-nitrobenzofurans by acylation of 2-(2-hydroxy-5-nitrophenyl)-1-aryl-ethanones and subsequent treatment of the esters with combinations of bases and proton acids or Lewis acids. This process can be used for the production of Dronedarone. Furthermore, novel intermediates for the manufacture of Dronedarone are provided.
|
申请公布号 |
CA2763472(A1) |
申请公布日期 |
2010.12.02 |
申请号 |
CA20102763472 |
申请日期 |
2010.05.26 |
申请人 |
SANOFI |
发明人 |
KRETZSCHMAR, GERHARD;KRAFT, VOLKER;OLPP, THOMAS;ROSSEN, KAI |
分类号 |
C07C205/43;A61K31/343;A61P9/06;C07D307/80 |
主分类号 |
C07C205/43 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|