发明名称 |
GENETIC IMMUNIZATION FOR PRODUCING IMMUNOGLOBULINS AGAINST CELL-ASSOCIATED ANTIGENS SUCH AS P2X7, CXCR7 OR CXCR4 |
摘要 |
The present invention relates to a method for generating immunoglobulin sequences against cell -associated antigens, more particularly, antigens that are membrane- anchored. The invention also provides immunoglobulin sequences obtainable by the method of the invention. Specifically, the present invention relates to the generation of immunoglobulin sequences by use of DNA vaccination. More specifically, the present invention relates to generation of immunoglobulin sequences in camelids, preferably directed against cell-associated antigens, in particular antigens with multiple transmembrane spanning domains, including GPCRs and ion channels, by DNA vaccination. Furthermore, the present invention relates to said immunoglobulin sequences against cell-associated antigens, more particularly, antigens that are membrane-anchored, such as e.g. GPCRs and ion channels, more preferably ion channels. |
申请公布号 |
WO2010070145(A3) |
申请公布日期 |
2010.12.02 |
申请号 |
WO2009EP67687 |
申请日期 |
2009.12.21 |
申请人 |
ABLYNX N.V.;LAEREMANS, TOON;STORTELERS, CATELIJNE;NOLTE, FRIEDRICH;GONZALEZ, MARIA;ASSUNCAO, JOANA;VAN ROMPAEY, PHILIPPE |
发明人 |
LAEREMANS, TOON;STORTELERS, CATELIJNE;NOLTE, FRIEDRICH;GONZALEZ, MARIA;ASSUNCAO, JOANA;VAN ROMPAEY, PHILIPPE |
分类号 |
C07K16/00;C07K16/28 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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