发明名称 |
RECOMBINANT HUMAN INTERFERON-LIKE PROTEINS |
摘要 |
This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology is described having enhanced anti-viral and anti-proliferative activities in comparison to naturally occurring human interferon alpha 2b (HuIFN-α2b). The invention encompasses a polynucleotide encoding the protein and recombinant vectors and host cells comprising the polynucleotide. Preferably the polynucleotide is selected from the group of polynucleotides each having a sequence at least 93% identical to SEQ ID: No. 1 and the protein is selected from the group of proteins each having an amino acid sequence at least 85% identical to SEQ ID No: 2. The proteins and compositions comprising the proteins can be used for treatment of conditions responsive to interferon therapy, such as viral diseases and cancer.
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申请公布号 |
US2010303759(A1) |
申请公布日期 |
2010.12.02 |
申请号 |
US20070665682 |
申请日期 |
2007.06.22 |
申请人 |
NOVAGEN HOLDING CORPORATION |
发明人 |
WANG HAITAO;MAO CHUNSHENG;LI JIZHI;WANG LING;DU YONG;LIU LONGBIN;XU JING;ZHANG RUI |
分类号 |
A61K38/21;A61P31/12;A61P35/04;C07H21/04;C07K14/555;C12N5/10;C12N15/63 |
主分类号 |
A61K38/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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