发明名称 |
MODIFIED PROTOZOAN EXPRESSING AT LEAST TWO VARIABLE SURFACE PROTEINS (VSP), A VACCINE COMPRISING IT AND PROCEDURES, USES, AND METHODS THEREOF |
摘要 |
Modified protozoa parasites comprising simultaneous expression on its surface of at least two variable surface proteins (VSP). The modified protozoa may also simultaneously express the complete repertoire of variable surface proteins. Protozoa show reduced expression of Dicer, RNA-dependant RNA-polymerase (RdRP) enzymes or both, wherein the RdRP gene and/or the Dicer gene has been silenced. The protozoan may be any protozoan showing an antigenic variation mechanism. |
申请公布号 |
WO2010064204(A3) |
申请公布日期 |
2010.12.02 |
申请号 |
WO2009IB55470 |
申请日期 |
2009.12.02 |
申请人 |
CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS YTECNICAS (CONICET);UNIVERSIDAD CATOLICA DE CORDOBA;INIS BIOTECH LLC;LUJAN, HUGO DANIEL |
发明人 |
LUJAN, HUGO DANIEL |
分类号 |
A61K35/68;A61K39/002;C07K14/44;C12N1/20;C12N15/113;C12R1/90 |
主分类号 |
A61K35/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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