APPARATUS AND METHODS FOR PERFORMING ELECTROCHEMICAL REACTIONS
摘要
<p>The invention is directed to apparatus and methods for delivering multiple reagents to, and monitoring, a plurality of analytical reactions carried out on a large-scale array of electronic sensors under minimal noise conditions. In one aspect, the invention provides method of improving signal-to-noise ratios of output signals from the electronic sensors sensing analytes or reaction byproducts by subtracting an average of output signals measured from neighboring sensors where analyte or reaction byproducts are absent. In other aspects, the invention provides an array of electronic sensors integrated with a microwell array for confining analytes and/or particles for analytical reactions and a method for identifying microwells containing analytes and/or particles by passing a sensor-active reagent over the array and correlating sensor response times to the presence or absence of analytes or particles. Such detection of analyte- or particle-containing microwells may be used as a step in additional noise reduction methods.</p>
申请公布号
WO2010138188(A1)
申请公布日期
2010.12.02
申请号
WO2010US01553
申请日期
2010.05.27
申请人
ION TORRENT SYSTEMS INCORPORATED;NOBILE, JOHN;ROTH, GEORGE, THOMAS;REARICK, TODD;SCHULTZ, JONATHAN;ROTHBERG, JONATHAN, M.;MARRAN, DAVID
发明人
NOBILE, JOHN;ROTH, GEORGE, THOMAS;REARICK, TODD;SCHULTZ, JONATHAN;ROTHBERG, JONATHAN, M.;MARRAN, DAVID