发明名称 |
IMAGING OF LIGHT SCATTERING TISSUES WITH FLUORESCENT CONTRAST AGENTS |
摘要 |
A system and method for non-invasive biomedical optical imaging and spectroscopy with low-level light is described. The technique includes a modulated light source coupled to tissue to introduce excitation light. Fluorescent light emitted in response to the excitation light is detected with a sensor. The AC intensity and phase of the excitation and detected fluorescent light is provided to a processor operatively coupled to the sensor. A processor employs the measured emission kinetics of excitation and fluorescent light to “map” the spatial variation of one or more fluorescence characteristics of the tissue and generate a corresponding image of the tissue via an output device. The fluorescence characteristic may be provided by exogenous contrast agents, endogenous fluorophores, or both. A technique to select or design an exogenous fluorescent contrast agent to improve image contrast is also disclosed.
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申请公布号 |
US2010305453(A1) |
申请公布日期 |
2010.12.02 |
申请号 |
US20100830089 |
申请日期 |
2010.07.02 |
申请人 |
SEVICK-MURACA EVA M;TROY TAMARA L;REYNOLDS JEFFERY S |
发明人 |
SEVICK-MURACA EVA M.;TROY TAMARA L.;REYNOLDS JEFFERY S. |
分类号 |
A61B6/00;A61B5/00 |
主分类号 |
A61B6/00 |
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