SPLIT-CORE-PARTICLES FOR THE PRESENTATION OF FOREIGN MOLECULES, ESPECIALLY FOR VACCINE APPLICATIONS, AND METHOD FOR THEIR PRODUCTION

摘要

Disclosed is a split-core carrier system which has, as separate polypeptides, the core N domain and the core C domain of the core protein of a hepatitis B virus and at least one foreign molecule based on a peptide or protein to which an immune response is to be elicited, said foreign molecule being fused to the C terminus of the core N domain or to the N terminus of the core C domain and the core protein being able to bind capsid-like particles, and the foreign molecule being fused to a core protein amino acid which is located between positions 73 and 94 of the core protein. Further disclosed are methods of preparing a carrier for foreign molecules, medicaments comprising capsid-like particles having a split-core carrier system and diagnostic agents thereof.