发明名称 |
FIBROBLAST GROWTH FACTOR MUTANTS HAVING IMPROVED FUNCTIONAL HALF-LIFE AND METHODS OF THEIR USE |
摘要 |
Mutant fibroblast growth factor (FGF) proteins having a polypeptide sequence with a high sequence identity to proteins encoded by members of the Fgf-1 subfamily of genes from a mammalian species, such as human, and with a specific amino acid substitution of an alanine at a position corresponding to amino acid position 66 of human FGF-1 with a cysteine and/or a specific amino acid substitution of a phenylalanine at a position corresponding to amino acid position 132 of human FGF-1 with a tryptophan (based on the 140 amino acid numbering scheme of human FGF-1) are provided. Other amino acid mutations or substitutions may be combined. Polynucleotide sequences encoding the mutant FGF proteins and host cells containing such polynucleotide sequences are provided. Methods of administering a mutant FGF protein to an individual to treat an ischemic condition or disease or a wound or tissue injury are also provided. |
申请公布号 |
WO2010135491(A2) |
申请公布日期 |
2010.11.25 |
申请号 |
WO2010US35513 |
申请日期 |
2010.05.20 |
申请人 |
FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION;BLABER, MICHAEL;LEE, JIHUN |
发明人 |
BLABER, MICHAEL;LEE, JIHUN |
分类号 |
A61K38/18;A61P9/10;A61P17/02;C07H21/00;C07K14/50;C12N5/07 |
主分类号 |
A61K38/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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