| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a stent carrying a vascular intimal hyperplasia inhibitor, which does not inhibit proliferation of endothelial cells, which stent is capable of releasing the drug in controlled manner. <P>SOLUTION: The stent includes a stent body of a cylindrical configuration, a first coated layer coating the outer surface of the stent body, and a second coated layer coating substantially completely over the first coated layer. The first coated layer is prepared of a first composition comprising a polymer and a vascular intimal hyperplasia inhibitor (preferably argatroban), which does not inhibit proliferation of endothelial cells, the weight compositional ratio of the polymer to the inhibitor being within the range of 8:2 to 3:7. The second coated layer is prepared of a polymer alone or a second composition comprising a polymer and a drug, the weight compositional ratio of the drug to 80 wt.% of the polymer being less than 20 wt.%. <P>COPYRIGHT: (C)2011,JPO&INPIT |
