Process for the preparation of compounds capable of activating cholinergic receptors

摘要

The present invention provides a method for synthesizing a compound of formula
or a pharmaceutically acceptable salt thereof, wherein
each of A, A I , and A" is H;
X is COR I ;
R' is C 1-5 alkyl;
X I is N;
mis1;
n is 1;
each of E', E", E III , E IV , and E V is H;
E VI is C 1-5 alkyl; and
each of Z I and Z II individually is H or C 1-5 alkyl;
or comprising coupling of a halo-substituted pyridine with an olefin containing protected amine functionality.