| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to a method for synthesis of novel sulphone derivatives of 2-nitro-2-(3-aryl-1,2,4-oxadiazol-5-yl)ethane of general formula I, which can be used as potential antimicobacterial preparations Ia-g, where la R-3-NO2C6H4, R1=NO2, R2=H; b R=3-NO2C6H4 R1=NO2, R2=CH3; c R=4-CH3OC6H4, R1=NO2, R2=H; d R=4-CH3OC6H4, R1=NO2, R1=CH3; e R=4-CH3OC6H4 R1=CO2Et, R2=H; f R=4-CH3OC6H4, R1=CO2Et, R2=CH3; g R=4-CH3C6H4, R1=CO2Et, R2=H. The method involves heating and mixing substituted 2-nitro1-chloro-2-(3-aryl-1,2,4-oxadiazol-5-yl)ethane with an equimolar amount of sodium 4-tolysulphinate in a solvent and then holding the reaction mixture at room temperature. ^ EFFECT: method avoids solvent preparation and increases output of the desired product. ^ 1 cl, 2 tbl, 7 ex |
