| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to a method of synthesis of N-substiuted salicylamide, involving reaction of a carsalam derivative with a chloro-substituted compound of formula (III) in the presence of a catalytic amount of a source of bromine ions, where n is an integer from 1 to 8, Q denotes a protected carboxylic group, and R5 and R6 are independently selected from a group containing hydrogen, -OH, NR3R4, halogen, C1-C4 alkyl, C1-C4 alkoxy, C2-C4 alkenyl, where R3 and R4 are each independently selected from a group containing hydrogen, -OH, C1-C4 alkyl, C1-C4 halogenalkyl, C1-C4 alkoxy and C2-C4 alkenyl. The invention also discloses a method for synthesis of a compound of general formula IV. ^ EFFECT: improved method for synthesis of N-substituted salicylamide enables to obtain large amounts of high-quality product. ^ 54 cl, 3 ex |
