A method of site specific labelling of an interferon molecule is provided. The method comprises the steps: a) providing a label molecule comprising a PEG moiety having an aldehyde or ketone moiety; b) providing an interferon molecule having a C terminal hydrazide moiety; and c) allowing the aldehyde or ketone moiety of the PEG moiety to react with the C terminal hydrazide of the interferon molecule to form a labelled interferon molecule, which comprises a PEG moiety attached to the C terminus of the interferon molecule via a hydrazone bond. Interferon molecules labelled using such a method are also described.
申请公布号
WO2010131015(A1)
申请公布日期
2010.11.18
申请号
WO2010GB00981
申请日期
2010.05.17
申请人
ALMAC SCIENCES (SCOTLAND) LIMITED;ROBERTS, JENNIFER;COTTON, GRAHAM