发明名称 PRION PROTEIN STRUCTURE TRANSFORMATION INHIBITOR AND UTILIZATION OF SAME
摘要 <p>Provided is a novel compound which is capable of inhibiting the formation of an infectious prion protein via binding to a normal prion protein. Specifically provided is a compound represented by formula (1). In formula (1), X represents a carbon atom or a nitrogen atom; R1 and R2 may be either the same or different and represent a hydrogen atom, an oxygen atom, a halogen atom, a hydroxy group, a mercapto group, a cyano group, a carboxy group, a carbamoyl group, an alkoxycarbonyl group, an acyloxy group, an acyl group, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, an optionally substituted amino group, etc.; and R3 to R6 may be either the same or different and represent a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, etc., provided that at least one of R1 and R2 represents a group other than hydrogen atom.</p>
申请公布号 WO2010131717(A1) 申请公布日期 2010.11.18
申请号 WO2010JP58129 申请日期 2010.05.13
申请人 GIFU UNIVERSITY;KUWATA KAZUO;KIMURA TSUTOMU;MUTO JUNJI 发明人 KUWATA KAZUO;KIMURA TSUTOMU;MUTO JUNJI
分类号 C07D213/40;A61K31/4025;A61K31/4439;A61P25/00;A61P43/00;C07D295/14;G01N33/15;G01N33/50 主分类号 C07D213/40
代理机构 代理人
主权项
地址