IMMUNOGENIC COMPOSITIONS AGAINST TUBERCULOSIS

摘要

Methods of preparing mutants of Mycobacterium tuberculosis whose genome comprises a disruption of a rv0348 gene are presented. The mutants may also include one or more other disrupted genes, such as disruptions in the ctpV, rv0990c and/or rv0971c genes. Compositions containing mutants with attenuated virulence and pathogenesis, which are capable of stimulation of an immune response against tuberculosis, are also described. Compositions and methods related to immunogenic compositions, which include an attenuated M. tb strain in which the M. tb genome includes a disruption of the rv0348 gene and, optionally, one or more of the ctpV gene, the rv0990c gene and the rv0971c gene, are also provided.