ANTI-TNFa FIBRONECTIN TYPE III DOMAIN BASED SCAFFOLD COMPOSITIONS, METHODS AND USES

摘要

A protein scaffold based on a consensus sequence of the tenth f?bronectin type III (FN3) repeat from human f?bronectin, preferably human Tenascin, that binds to human TNFa including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.