SYSTEMS AND METHODS FOR TAILORING ACUTE AND CHRONIC VIRAL INFECTION TREATMENTS TO INCREASE THE PROBABILITY OF CURE FOR A GIVEN SUBJECT

摘要

In various embodiments, systems and methods are provided for increasing the likelihood of a sustained virological response or cure using a model of patient physiology incorporating a subjects race, gender, age, weight, concomitant medicines and disease state, immune response status, and responsiveness to drug therapies to simultaneously characterize the change in viral burden in the subject in terms of velocity of viral load decline. In an embodiment, once viral load in a subject is below a physical measurement limit, the model can extrapolate the subjects observed viral velocity toward a physiological target shown to be highly correlated with cure. In further embodiments, the model can be used for personalized medicine - the right drug at the right dose for the right treatment duration for the right patient. Accordingly, the model can provide optimal value for treatment and reducing the high cost of side effects.