发明名称 |
PHOSPHORYLATION OF HISTONE H3 AT THREONINE 11 - A NOVEL EPIGENETIC MARK FOR TRANSCRIPTIONAL REGULATION |
摘要 |
The present invention relates to a process for controlling at least one androgen receptor- (AR-) regulated mechanism in mammalian cells under histone-phosphorylating conditions, said process comprising allowing at least one inhibitor with specificity for at least one protein kinase C-related kinase (PRK) to act on said at least one PRK1 thereby modulating, preferably down-regulating, the activity of said at least one PRK and optionally blocking said at least one androgen receptor-regulated mechanism in said mammalian cells.
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申请公布号 |
US2010285026(A1) |
申请公布日期 |
2010.11.11 |
申请号 |
US20080669294 |
申请日期 |
2008.05.27 |
申请人 |
UNIVERSITAETSKLINIKUM FREIBURG |
发明人 |
SCHUELE ROLAND;METZGER ERIC |
分类号 |
A61K39/395;A61P35/00;C12N5/02;C12Q1/48 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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