发明名称 |
3,4-SUBSTITUTED PYRROLIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE |
摘要 |
The present invention is directed to 3,4-substituted pyrrolidine compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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申请公布号 |
US2010280009(A1) |
申请公布日期 |
2010.11.04 |
申请号 |
US20080747605 |
申请日期 |
2008.12.10 |
申请人 |
STACHEL SHAWN J;STEELE THOMAS;PETROCCHI ALESSIA |
发明人 |
STACHEL SHAWN J.;STEELE THOMAS;PETROCCHI ALESSIA |
分类号 |
A61K31/4025;A61K31/438;A61K31/4439;A61K31/5377;A61K31/55;A61P25/28;C07D401/06;C07D403/06;C07D405/14;C07D409/14;C07D413/06;C07D413/14;C07D491/107 |
主分类号 |
A61K31/4025 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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