METHOD FOR PRODUCING INJECTABLE PREPARATION CONTAINING CEFTRIAXONE SODIUM AND TAZOBACTAM SODIUM

摘要

A method for producing injectable preparation containing ceftriaxone sodium and tazobactam sodium, involves the steps of: (a) weighing raw materials of ceftriaxone sodium, tazobactam sodium, sterile water for injection, the mixture of ethyl acetate and isopropyl alcohol, and anhydrous ethanol with the weight ratio of 3-5: 1: 2: 5: 9, wherein the volume ratio of ethyl acetate to isopropyl alcohol is 1: 2-4; (b) dissolving ceftriaxone sodium and tazobactam sodium in sterile water for injection, then adding activated charcoal and performing filtration; (c) adding the mixture of ethyl acetate and isopropyl alcohol to the filtrate and stirring them well, then adding ceftriaxone sodium crystal seed to the solution to crystallize, and finally washing the crystal with anhydrous ethanol and drying the crystal; and (d) freeze-drying to obtain injectable preparation containing ceftriaxone sodium and tazobactam sodium. The preparation has good uniformity, high purity and safety.