发明名称 |
PROCESS FOR PRODUCTION OF THIOPHENE COMPOUND AND INTERMEDIATE THEREOF |
摘要 |
<p>To provide a novel process for producing a 2-aryl-3-hydroxy-4-substituted carbonyl thiophene compound or an intermediate thereof useful as an intermediate for production of medicines and agricultural chemicals. A 2-aryl acetate compound represented by the formula (1):
wherein R 1 is an aryl group or the like, R 4 is a C 1-3 alkyl group or the like, and X is a leaving group, is reacted with a thioacetic acid compound to form a thioacetyl compound (3), the thioacetyl compound (3) is reacted with a vinyl ketone compound to form a ³-ketosulfide compound (5), which is cyclized under basic conditions to form a dihydrothiophene compound (6), and the dihydrothiophene compound (6) is oxidized by using an oxidizing agent to produce a 2-aryl-3-hydroxy-4-substituted carbonyl thiophene compound (7).</p> |
申请公布号 |
EP2246343(A1) |
申请公布日期 |
2010.11.03 |
申请号 |
EP20090714127 |
申请日期 |
2009.02.27 |
申请人 |
NISSAN CHEMICAL INDUSTRIES, LTD. |
发明人 |
YANAGIHARA, KAZUFUMI;UMEZAWA, SHINGO;MIYAJI, KATSUAKI |
分类号 |
C07D333/32;C07C319/18;C07C323/56;C07C327/32 |
主分类号 |
C07D333/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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