Pharmaceutical composition in the form of a gastric-resident tablet containing an active principle

摘要

Disclosed is a pharmaceutical composition in the form of a gastric retention matrix tablet comprising an active ingredient, comprising one or more phases, wherein at least one of the phases contains at least, as excipients: a) povidone and/or polyvinyl acetate in proportions ranging from 30 to 80% by weight of the phase, b) crospovidone in proportions ranging from 5 to 25% by weight of the phase, and c) carbomer in proportions ranging from 5 to 40% by weight of the phase. The composition is designed to rapidly swell up on contact with gastric juices so that has a longer residence in the stomach and avoids the premature release of the active ingredient. An example of a suitable active ingredient is Alfuzosin hydrochloride.