Selected CGRP antagonists, method for the production thereof and their use as medicaments

摘要

Disclosed are aryl-substituted piperidine-1-carboxylate derivatives as represented by the general formula (I), wherein: A and X independently represent an oxygen or sulphur atom; D, E, G, M and Q independently of one another in each case represent a methyne group or a nitrogen atom which may be substituted as defined herein; R1 represents 1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one-3-yl, 3,4-dihydro-1H-quinazolin-2-one-3-yl, 5-phenyl-2,4-dihydro-1,2,4-triazol-3-one-2-yl, 1,3-dihydroimidazo[4,5-c]quinolin-2-one-3-yl, 1,3-dihydro-naphth[1,2-d]imidazol-2-one-3-yl, 1,3-dihydro-benzimidazol-2-one-3-yl, 4-phenyl-1,3-dihydro-imidazol-2-one-1-yl, 3,4-dihydro-1H-thieno[3,2-d]pyrimidin-2-on-3-yl or a 3,4-dihydro-1H-thieno[3,4-d]pyrimidin-2-on-3-yl group; and where the remaining substituents are as defined herein. Also disclosed is the use of a compound as defined above for preparing a pharmaceutical composition for the acute and prophylactic treatment of headaches, for the treatment of non-insulin-dependent diabetes mellitus ("NIDDM"), complex regional pain syndrome (CRPS1), cardiovascular diseases, morphine tolerance, diarrhoea caused by clostridium toxin, skin diseases, inflammatory diseases, diseases accompanied by excessive vasodilatation and resultant reduced circulation of the blood, for alleviating pain or for preventive or acute therapeutic treatment of the symptoms of menopausal hot flushes caused by vasodilatation and increased blood flow in oestrogen-deficient women and hormone-treated patients with prostate carcinoma.