| 摘要 |
The present invention relates to novel pharmaceutical compositions suitable for use as foams, notably rectal foams. According to the present invention there is provided a pharmaceutical composition suitable for use as a foam comprising 5 -ASA or a pharmaceutically acceptable salt thereof and a silicone oil. The pharmaceutical composition may remain substantially fluid upon pressurisation, avoiding, for example, significant crystallisation of the active principle. The pharmaceutical composition also provides further physical advantages such as dose reproducibility of the active principle and, if crystallisation does occur, ease of re- suspension. The invention additionally provides a complementary delivery device and/or enhanced foam-forming properties of the pharmaceutical composition. |
