Silk fibroin textile structures as biomimetic prosthetics for the regeneration of tissues and ligaments

摘要

The invention concerns a silk fibroin weave structure comprising a concentric tubular outer sheath and an inner core, wherein said sheath is a woven fabric with interlaced loop and said core is a woven fabric with interlaced loop or is braided using a braiding machine. The silk fibroin used to weave the structure of the invention is a silk yarn with a linear density comprised of between approx. 40 den and approx. 640 den, preferably, the linear density is approx. 80 den or approx. 320 den. The core of the structure has a mean pore area comprised of between 0.001 and 2.000 mm 2 , while the outer sheath has a mean pore area comprised of between 0.005 and 15.000 mm 2 . The structure of the invention is used for the in vivo or in vitro regeneration of ligaments, particularly the anterior cruciate ligament, tendons, muscles and blood vessels. Furthermore, the structure promotes in vivo and in vitro cell adhesion and proliferation.