发明名称 |
METHOD OF INHIBITING ABCG2 AND RELATED TREATMENTS |
摘要 |
Disclosed are methods of enhancing the chemotherapeutic treatment of tumor cells, reducing resistance of a cancer cell to a chemotherapeutic agent, a method of inhibiting ABCG2 or MRP1 in a mammal afflicted with cancer, and a method of increasing the bioavailability of an ABCG2 substrate drug in a mammal. The methods comprise administering peliomycin and other compounds described herein.
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申请公布号 |
US2010267652(A1) |
申请公布日期 |
2010.10.21 |
申请号 |
US20080742039 |
申请日期 |
2008.11.05 |
申请人 |
HENRICH CURTIS J;BOKESCH HEIDI R;BATES SUSAN E;ROBEY ROBERT W;SHUKLA SUNEET;AMBUDKAR SURESH V;DEAN MICHAEL C;MCMAHON JAMES B |
发明人 |
HENRICH CURTIS J.;BOKESCH HEIDI R.;BATES SUSAN E.;ROBEY ROBERT W.;SHUKLA SUNEET;AMBUDKAR SURESH V.;DEAN MICHAEL C.;MCMAHON JAMES B. |
分类号 |
A61K31/7042;A61K31/295;A61K31/40;A61K31/4439;A61K31/4985;A61K31/519;A61P35/04 |
主分类号 |
A61K31/7042 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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