发明名称 |
4-AZETIDINYL-1-HETEROARYL-CYCLOHEXANE ANTAGONISTS OF CCR2 |
摘要 |
The present invention comprises compounds of Formula (I). Formula (I). wherein: X, R1, R2, R3, and R4 are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).
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申请公布号 |
CA2758918(A1) |
申请公布日期 |
2010.10.21 |
申请号 |
CA20102758918 |
申请日期 |
2010.04.15 |
申请人 |
JANSSEN PHARMACEUTICA NV |
发明人 |
ZHANG, XUQING;HUFNAGEL, HEATHER RAE;CAI, CHAOZHONG;LANTER, JAMES;MARKOTAN, THOMAS P.;SUI, ZHIHUA |
分类号 |
C07D401/08;A61K31/433;A61K31/437;A61K31/4427;A61P3/10;A61P29/00;C07D403/08;C07D413/08;C07D417/08;C07D471/04 |
主分类号 |
C07D401/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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