<p>This invention relates to altered forms of members of the RNase A superfamily. An RNase A can be modified to be cytotoxic by altering its amino acid sequence so that it is not bound easily by the ribonuclease inhibitor while still retaining catalytic properties. While earlier work had identified some modifications to RNase A that would result in cytotoxicity, the use of the FADE algorithm for molecular interaction analysis has led to several other locations that were candidates for modification. Some of those modifications did result in RNase A variants with increase cytotoxicity.</p>
申请公布号
EP1910541(B1)
申请公布日期
2010.10.20
申请号
EP20060784926
申请日期
2006.06.16
申请人
WISCONSIN ALUMNI RESEARCH FOUNDATION
发明人
RAINES, RONALD, T.;MITCHELL, JULIE, C.;RUTKOSKI, THOMAS, J.