发明名称 Isoquinolinone derivatives substituted with a purine useful as PI3K inhibitors
摘要 Provided herein are substituted bicyclic compounds, e.g., compounds of Formula IV, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for inhibiting phosphatidyl inositol-3 kinase (PI3 kinase), e.g., for the treatment of various diseases and conditions associated with PI3 kinase activity, including but not limited to, cancer, inflammatory disease, immune disease, and respiratory disease.
申请公布号 EP2240451(A1) 申请公布日期 2010.10.20
申请号 EP20090700424 申请日期 2009.01.05
申请人 INTELLIKINE, INC. 发明人 REN, PINGDA;LIU, YI;WILSON, TROY, EDWARD;LI, LIANSHENG;CHAN, KATRINA;ROMMEL, CHRISTIAN
分类号 C07D473/34;A61K31/519;A61K31/52;A61P19/00;C07D487/04 主分类号 C07D473/34
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